Search results for "firing rate"
showing 4 items of 4 documents
Reduced firing rates of pyramidal cells in the frontal cortex of APP/PS1 can be restored by acute treatment with levetiracetam
2020
Contains fulltext : 229488.pdf (Publisher’s version ) (Open Access) Contains fulltext : 229488pre.pdf (Author’s version preprint ) (Open Access) In recent years, aberrant neural oscillations in various cortical areas have emerged as a common physiological hallmark across mouse models of amyloid pathology and patients with Alzheimer's disease. However, much less is known about the underlying effect of amyloid pathology on single cell activity. Here, we used high-density silicon probe recordings from frontal cortex area of 9-month-old APP/PS1 mice to show that local field potential power in the theta and beta band is increased in transgenic animals, whereas single-cell firing rates, specifica…
Decreased motor unit firing rate and force control in older men
2006
Introduction Ageing is related to muscle atrophy that leads to decreases in muscle force. The largest changes are found in fast muscle fibres and fast force production, reducing the capability to recover from sudden balance disturbances. Also ageing-related decrease in force control has been found, as indicated by an increase in force fluctuations and motor unit (MU) firing variability (Galganski et al. 1993). Possibly due to differences in measurement protocols and muscles, the results concerning the effects of ageing on motor unit firing rate are, however, somewhat contradictory (for review, see Roos et al. 1997). The purpose of the present study was to investigate the age-related changes…
Neural Adaptations to Strength Training
2018
Scientific study of strength training has revealed numerous physiological mechanisms that contribute to: (1) acute fatigue from a single strength training session and (2) chronic adaptation to repetitive and systematic strength training. Therefore, the purpose of this chapter is initially to discuss potential neural mechanisms that influence force production from the perspective of a single repetition. Thereafter, the chapter will highlight scientific evidence for candidate neural mechanisms that acutely limit force production during a single strength training session and long-term adaptations caused by strength training. For some of these potential neural mechanisms, there is strong scient…
Force Control and Motor Unit Firing Behavior Following Mental Fatigue in Young Female and Male Adults
2020
Purpose: The neuromuscular mechanisms leading to impaired motor performance in the presence of mental fatigue remain unclear. It is also unknown if mental fatigue differentially impacts motor performance in males and females. The purpose of this study was to assess the impact of mental fatigue on force production and motor unit (MU) firing behavior in males and females. Methods: Nineteen participants performed 10-s isometric dorsiflexion (DF) contractions at 20 and 50% maximum voluntary contraction (MVC) before, during, and after completing 22 min of the psychomotor vigilance task (PVT), to induce mental fatigue. The DF force and indwelling MU firing behavior of the tibialis anterior (TA) w…